Bell's Palsy Research
Jalaludin M.A., Methods Find
Exp Clin Pharmacol 1995;17:539–44.
Sixty patients with Bell's palsy
were included in an open randomized trial. Patients were assigned
into three treatment groups: steroid (group 1), methylcobalamin
(group 2) and methylcobalamin + steroid (group 3). Comparison
between the three groups was based on the number of days needed
to attain full recovery, facial nerve scores, and improvement
of concomitant symptoms. The time required for complete recovery
of facial nerve function was significantly shorter ( p <
0.001) in the methylcobalamin (mean of 1.95 +/- 0.51 weeks)
and methylcobalamin plus steroid groups (mean of 2.05 +/- 1.23
weeks) than in the steroid group (mean of 9.60 +/- 7.79 weeks).
The facial nerve score after 1-3 weeks of treatment was significantly
more severe (p < 0.001) in the steroid group compared to
the methylcobalamin and methylcobalamin plus steroid groups.
The improvement of concomitant symptoms was better in the methylcobalamin
treated groups than the group treated with steroid alone.
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