Research Involving
MSM and DMSO
-
Polar solvents
and colon cancer. Use of polar solvents in chemoprevention
of 1,2-dimethylhydrazine-induced colon cancer
-
Polar solvents
in the chemoprevention of dimethylbenzanthracene-induced
rat mammary cancer
Cancer 1988 Sep 1;62(5):944-8
To examine the effect of the
polar solvents on 1,2-dimethylhydrazine (DMH)-induced colon
cancer, 100 male Sprague-Dawley rats were randomly allocated
to a control and three treatment groups. Treated animals received
N-methylformamide (NMF), dimethylsulfoxide (DMSO), or methylsulfonylmethane
(MSM) added to drinking water 1 week before carcinogen injections
commenced and for the duration of the experiment. Primary tumors
were detected by serial laparotomy under ether anesthesia performed
at 2-month intervals and commencing after carcinogen injections
had been completed. The average time to tumor onset was significantly
delayed in rats receiving NMF and MSM (P = 0.0141 and 0.0398
respectively, Mantel-Haenszel test). In addition, fewer poorly
differentiated tumors were noted in treatment groups. No weight
loss or toxicity was observed. These findings demonstrate that
the polar solvents significantly reduce the latent period to
tumor onset in DMH-induced colon cancer and indicate the need
to further investigate such compounds as chemopreventive agents.
Arch Surg 1986 Dec;121(12):1455-9
Differentiating agents have been
used experimentally and clinically as an adjuvant in the treatment
of cancer, but their role in chemoprevention is limited. We
used 5% dimethylsulfoxide (DMSO), 1% and 4% methylsulfonylmethane
(MSM), 0.3% N-methylformamide (NMF), and retinol acetate (RA)
in the chemoprevention of rat mammary breast cancer. One hundred
fifty 42-day-old Sprague-Dawley rats were randomized into six
groups (control, RA, DMSO, 1% MSM, NMF, and 4% MSM) and received
chemopreventive agents along with standard rat chow ad libitum.
Eight days later, 15 mg of 7,12-dimethylbenzanthracene was given
by oral gastric intubation. The animals were examined weekly
for tumor incidence and size (biplanar analysis). Animals were
followed up for 240 to 300 days. Tumor incidence was not statistically
affected. Time to appearance (latency period) of both tumors
and cancers were prolonged by NMF, DMSO, and 4% MSM. Doubling
times of all cancers produced were prolonged by DMSO and RA.
No group exhibited toxic reactions or significant weight loss.
Polar solvents and differentiating agents, specifically NMF,
DMSO, and 4% MSM, were effective in the chemoprevention of dimethylbenzanthracene-induced
mammary cancers.
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